The Batista Lab
Each month, Simply Blood spotlights a lab contributing to the fields of hematology, immunology, stem cell research, cell and gene therapies, and more. Get to know groups doing cutting edge research from around the world! This month, we are featuring the Batista Lab out of University of Utah - Huntsman Cancer Institute, USA.
Can you talk a little bit about your training and when you started your own lab?
During my Ph.D., I trained in DNA damage responses, focusing on how genotoxic stress and defects in repair pathways drive genome instability in cancer cells. I then pursued postdoctoral training at Stanford University, where I transitioned into telomere biology and demonstrated that telomere shortening impairs stem cell self-renewal using human iPS cell models of telomere syndromes. This work established a direct link between telomerase dysfunction and loss of tissue regenerative capacity, particularly in the hematopoietic system. From there I started my independent laboratory in 2014 at Washington University School of Medicine, where I continued to study telomerase regulation and the role of telomere dysfunction in blood development and disease.
What does your lab study?
My lab studies how telomerase and RNA processing pathways regulate hematopoietic development and how their dysfunction leads to disease. We are particularly interested in how the mechanisms controlling the biogenesis, stability, and decay of non-coding RNAs influence stem cell function and hematopoietic development. We have identified different regulators of RNA stability that when impaired, severely impact genomic integrity and compromise blood formation. Ultimately, our goal is to identify novel therapeutic strategies to improve outcomes for patients with hematologic and telomere-related disorders.
What do you think is important for someone to know when they start their own lab?
- Build a strong mentoring committee early, not necessarily with people who do similar research but with people you trust who will give honest advice as you move forward.
- Avoid becoming an island. Try to actively engage and collaborate with faculty at your new institution.
- Expand your research thoughtfully, but stay focused! Growth is important, but dilution of your core strengths can be detrimental.
- Make sure you understand the constantly evolving funding landscape.
- And above all: keep doing great science.
When did you move to the University of Utah/Huntsman Cancer Institute?
I moved my lab from WashU to the Huntsman Cancer Institute earlier this year, January 2026
What has been the hardest part about moving a lab across the country?
To deal with the unexpected. From delays in receiving new equipment and reagents, to having to adapt to completely different internal software platforms. Hiring of new qualified personnel, and above all, how to efficiently transfer grants…
What are the qualities you look for in your lab members?
I look for people who genuinely love science and are driven by curiosity to understand fundamental biological questions. A strong grasp of the field is important, along with the ability to think critically and have the courage to try new things. Pushing boundaries is how our most exciting research happens.
What is the best part of being a PI?
The freedom to do what we like, what we think is important. To try to come with novel alternatives to help patients live a better and more fulfilling life. And to come to a work environment where you are surrounded by brilliant people is incredible!
What is your favorite thing about Utah?
For sure the incredible outdoors!
What is one of your favorite science memories?
So many. But I think the first time I entered my own lab, completely empty, and realized it was now all up to me, is something I will never forget. A great feeling!
What is something about yourself others would be surprised to know about you?
That I am the only Portuguese person ever to be horrible at soccer, which lead to a very traumatic youth 😀
Blog post contributed by Adrienne Dorrance, PhD of the ISEH Publications Committee.
Please note that the statements made by Simply Blood authors are their own views and not necessarily the views of ISEH. ISEH disclaims any or all liability arising from any author's statements or materials.