2024 New Investigator Award Winners
PhD Students
First prize - Dirk van Bekkum Award
Andy Zeng, BSc, Princess Margaret Cancer Centre
Precise single-cell transcriptomic mapping of normal and leukemic cell states reveals unconventional lineage priming in acute myeloid leukemia
Second prize - T. Ray Bradley Award
Justin Thomas, MHS, Fred Hutchinson Cancer Center
Development of CD90-targeted in vivo hematopoietic stem cell gene therapy
Third prize - Greg Johnson Award
Zhiqian Zheng, MS, the University of Tokyo
TNFα-driven Interplay between Hematopoietic Stem Cells and Antigen-Specific Cytotoxic T Cells
Post-doc
First prize - Eugene Cronkite Award
Maria Jassinskaja, PhD, York Biomedical Research Institute, Department of Biology, University of York
Intra- and extracellular proteome dynamics during normal and malignant hematopoietic stem cell expansion
Second prize - George Brecher Award
Charles Dussiau, PharmD, PhD, EMBL and DKFZ
Aging hematopoiesis: beyond the deterministic dogma of hematopoietic stem cell dysfunction
Third prize - Christa Muller-Sieburg Award
Xinjian Mao, PhD, Stowers Institute for Medical Research
Spatial transcriptomics characterize dynamic and polarized niche cells and signals for embryonic hematopoiesis
2023 New Investigator Award Winners
PhD Students
First prize - Dirk van Bekkum Award
Foteini Fotopoulou, DKFZ, HI-STEM, Germany
During ageing, the hematopoietic stem cell genome is protected by dormancy, not apoptosis
Second prize - T. Ray Bradley Award
Daniel Tavakol, Columbia University, USA
Bioengineered iPSC-derived models of human bone marrow for studies of systemic injury and disease
Third prize - Greg Johnson Award
Alec Geßner, Goethe University Frankfurt, Germany
Single-cell barcoding revealed a differentiation hierarchy of leukemia-initiating stem cells in adult acute lymphoblastic leukemia
Post-doc
First prize - Eugene Cronkite Award
Samuel Taylor, Albert Einstein College of Medicine, USA
Transcription factor redistributors actuate non-canonical gene circuits to drive AML differentiation
Second prize - George Brecher Award
Chloé Baron, Boston Children’s Hospital, USA
Cellular barcoding of the leukemic niche reveals an apelin-mediated clonal expansion of niche endothelial and mesenchymal stromal cells
Third prize - Christa Muller-Sieburg Award
Elanor Wainwright, Peter MacCallum Cancer Centre, Australia
Understanding how the tissue microenvironment directs cell fate in haematopoietic stem and progenitor cells
2022 New Investigator Award Winners
PhD Students
First prize - Dirk van Bekkum Award
YuWei Zhang, Max Planck Institute of Immunobiology and Epigenetics, Germany
GPRC5Cis critical for healthy hematopoiesis and acute myeloid leukemia
Second prize - T. Ray Bradley Award
Thomas Olender, Ottawa Hospital Research Institute, Canada
Disruption of CTCE binding by the oncogenic transcription factor TLX1 alters the genomic topology in T cell acute lymphoblastic leukemia (T-ALL)
Third prize - Greg Johnson Award
Tomoya Isobe, Wellcome-MRC Cambridge, UK
Integrative single-cell analysis of preleukaemic mutant mouse models illustrates mutation-specific haematopoietic perturbations
Post-doc
First prize - Eugene Cronkite Award
Nouraiz Ahmed, Department of Biosystems Science & Engineering, Switzerland
Live single cell quantification of gata switch dynamics during adult and developmental erythropoiesis identify novel regulatory mechanisms of erythropoiesis
Second prize - George Brecher Award
Jayna Mistry, The Jackson Laboratory, USA
DNMT3A-Mutant hematopoietic progenitor cells induce senescence of bone marrow stroma to accelerate clonal hematopoiesis and transformation to acute myeloid leukemia
Third prize - Christa Muller-Sieburg Award
Chiara Pirillo, The Beatson Institute for Cancer Research, UK
Metalloproteinase inhibition reduces AML growth, prevents stem cell loss, and improves chemotherapy effectiveness
2021 New Investigator Award Winners
PhD Students
First prize - Dirk van Bekkum Award
Bianca Ulloa, Albert Einstein College of Medicine, USA
Definitive Hematopoietic Stem Cells Minimally Contribute to Embryonic Hematopoiesis
Second prize - T. Ray Bradley Award
Emily Mitchell, Wellcome Sanger Institute, UK
Haematopoietic stem cell clonal dynamics across the human lifespan
Third prize - Greg Johnson Award
Maria Aivalioti, Albert Einstein College of Medicine, USA
PU.1-dependent enhancer decommissioning separates clonal hematopoiesis from malignant transformation
Post-doc
First prize - Eugene Cronkite Award
Nicole Mende, University of Cambridge, UK
Integrated single cell analysis identifies unique molecular and functional features of extramedullary haematopoiesis in humans
Second prize - George Brecher Award
Laura Garcia Prat, University Health Network, Canada
TFEB-mediated endo-lysosomal activity controls hematopoietic stem cell fate
Third prize - Christa Muller-Sieburg Award
Laure Maneix, Baylor College of Medicine, USA
Cyclophilin A regulates protein phase separation and mitigates hematopoietic stem cell aging
2020 New Investigator Award Winners
PhD Students
First prize - Dirk van Bekkum Award
Luke Harland, University of Oxford, United Kingdom
Eomesodermin Governs the Hemogenic Competence of Murine Yolk-Sac Mesodermal Progenitors
Second prize - T. Ray Bradley Award
Justin Wheat, Department of Cell Biology, Albert Einstein College of Medicine, United States
Transcriptional Dynamics of the PU.1-Gata Network at Single Molecule Resolution in Hematopoietic Stem Cells
Third prize - Greg Johnson Award
Vasiliki Symeonidou, University of Edinburgh, United Kingdom
Exploiting the foetal origin of MLL-AF4-driven Acute Lymphoblastic Leukaemia
Post-doc
First prize - Eugene Cronkite Award
Marlies Rossmann, Harvard University, United States
Transcriptional regulation of mitochondrial metabolism by TIF1gamma drives erythroid progenitor differentiation
Second prize - George Brecher Award
Dirk Loeffler, Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland
Asymmetric cell division modulates human hematopoietic stem cell fates
Third prize - Christa Muller-Sieburg Award
William Grey, The Francis Crick Institute, United Kingdom
Activation of the Receptor Tyrosine Kinase (RET) by GDNF/GFR-1 Improves Cord Blood-Derived HSC in vitro Expansion and in vivo Engraftment
Please visit Experimental Hematology online to view the winning abstracts.
2019 New Investigator Award Winners
PhD Students
First prize - Dirk van Bekkum Award
Ruth Howe, Albert Einstein College of Medicine, USA (2024)
Deficiency of the novel tumor suppressor C15orf65 causes multiple myeloma and plasma cell malignancy
Second prize - T. Ray Bradley Award
Dorit Schneider, Pediatric Hematology and Oncology - Hannover Medical School, Germany (2026)
Ezh2 loss cooperates with loss of Bcor, Tet2 and Runx1 during leukemogenesis and reactivates a fetal gene signature
Third prize - Greg Johnson Award
Olivia Cooney, Baker Heart and Diabetes Institute, Australia (2025)
Rheumatoid Arthritis increases sympathetic nervous system driven hematopoietic stem cell mobilisation and atherogenesis
Post-doc
First prize - Eugene Cronkite Award
Matthew Witkowski, New York University School of Medicine, USA (2029)
The relapsed B-cell acute lymphoblastic leukaemia immune microenvironment
Second prize - George Brecher Award
Giorgia Scapin, Nationwide Children's Hospital, Ohio State University College of Medicine, USA (2028)
Pulsation in blood vessels stimulates mechanosensitive and epigenetic mechanisms to promote the birth of hematopoietic stem cells
Third prize - Christa Muller-Sieburg Award
Alejo Rodriguez-Fraticelli, Boston Children's Hospital, Harvard Medical School, USA (2027)
Simultaneous lineage and transcriptional analysis of single HSCs identifies mechanisms of functional heterogeneity
Please visit Experimental Hematology online to view the winning abstracts.
2018 New Investigator Award Winners
PhD Students
First prize - Dirk van Bekkum Award
Rachel Hynes-Smith, University of Nebraska Medical Center, USA
Loss of FBXO9 Accelerates the Onset of Acute Myeloid Leukemia
Second prize - T. Ray Bradley Award
Jiahao Chen, Albert Einstein College of Medicine, USA
MDS Progression to AML at the Stem Cell Level
Third prize - Greg Johnson Award
Gabriela Kidrova, University of Toronto, Canada
miR-130a regulates hematopoietic stem cell self-renewal by repressing several chromatin modifiers and its overexpression is associated with acute myeloid leukemia
Post-doc
First prize - Eugene Cronkite Award
Konstantinos Kokkaliaris, ETH Zurich, Switzerland
Quantitative bone-marrow imaging reveals niche signatures of distinct types of adult and juvenile hematopoietic stem cells
Second prize - George Brecher Award
Larry Luchsinger, Columbia University Medical Center, USA
Maintenance of Hematopoietic Stem Cells in a Low Calcium Environment
Third prize - Christa Muller-Sieburg Award
Philip Boulais, Albert Einstein College of Medicine, USA
Stromal-dependent hematopoietic progenitors permeate the CD45CD31Ter119 bone marrow cell fraction
Please visit Experimental Hematology online to view the winning abstracts.
2017 New Investigator Award Winners
PhD Students
First prize - Dirk van Bekkum Award
Johannes Jung, European Research Institute for the Biology of Ageing, The Netherlands
CBX7 regulates self-renewal of human benign HSC and induces terminal differentiation of AML cells
Second prize - T. Ray Bradley Award
Simon Renders, Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Germany
Neogenin regulates hematopoietic stem cell quiescence and maintenance
Third prize - Greg Johnson Award
Petter Säwen, Department of molecular hematology, Lund University, Sweden
Hematopoietic stem cells are active contributors to hematopoiesis in steady state
Post-doc
First prize - Eugene Cronkite Award
Luis Carvajal, Albert Einstein College of Medicine, USA
Dual inhibition of Hdmx and Hdm2 in acute myeloid leukemia
Second prize - George Brecher Award
Alejo Rodriguez-Fraticelli, Boston Children's Hospital / Harvard Stem Cell and Regenerative Biology, USA
Clonal analysis of lineage fate in unperturbed hematopoiesis
Third prize - Christa Muller-Sieburg Award
Bilyana Stoilova, Weatherall Institute of Molecular Medicine, University of Oxford, UK
Single cell assays unveil functional and transcriptional heterogeneity of human hemopoietic lympho-myeloid progenitors
Please visit Experimental Hematology online to view the winning abstracts.
2016 New Investigator Award Winners
PhD Students
First prize - Dirk van Bekkum Award
Sisi Chen, Indiana University, USA
Gain-of-function mutant p53 drives the development of pre-leukemic hematopoietic stem cells through modulating epigenetic pathways
Second prize - T. Ray Bradley Award
Sandra Capellera-Garcia, Lund Stem Cell Center, Sweden
Defining the minimal factors required for erythropoiesis through direct lineage conversion
Third prize - Greg Johnson Award
Marissa Rashkovan, IRCM, Canada
Notch1-induced T cell leukemogenesis requires the c-Myc cofactor and BTB-POZ domain protein Miz-1 to control the activation of p53
Post-doc
First prize - Eugene Cronkite Award
Evgenia Verovskaya, University of California, San Francisco, USA
Remodeling of the multipotent progenitor (MPP) pool directly contributes to blood aging
Second prize - George Brecher Award
Benjamin Cao, Commonwealth Scientific and Industrial Research Organisation, Australia (2038)
Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist
Third prize - Christa Muller-Sieburg Award
Nina Cabezas-Wallscheid, German Cancer Research Center, Germany (2039)
Exit from HSC dormancy by a continuous upregulation of metabolism is controlled via vitamin A/retinoic acid
Please visit Experimental Hematology online to view the winning abstracts.
2015 New Investigator Award Winners
PhD Students
First prize - Dirk van Bekkum Award
Diana Dou, Broad Stem Cell Research Center, UCLA, USA
Short Talk: Medial HOXA gene expression is required for establishing “stemness” in human HSCs
Second prize - T. Ray Bradley Award
Julien Patenaude, Institute for Research in Immunology and Cancer (IRIC). Canada
Short Talk: Elucidating the post-natal role of SCA1+ thymic mesenchymal cells
Third prize - Greg Johnson Award
Roman Galeev, Lund University, Sweden
Short Talk: Cohesin genes are critical regulators of HSC renewal
Post-doc
First prize - Eugene Cronkite Award
Bastien Gerby, Institute of Research in Immunology and Cancer (IRIC), Canada
Short Talk: Targeting pre-leukemic stem cells in T-acute lymphoblastic leukemia
Second prize - George Brecher Award
Amelie Guitart, MRC Centre for Regenerative Medicine, University of Edinburgh, UK
Short Talk: Dual function of fumarate hydratase in haematopoietic stem cell fates
Third prize - Christa Muller-Sieburg Award
Isabel Beerman, Harvard University/Boston Children's Hospital, USA
Short Talk: Age-associated Clonal Dominance of Myeloid-biased HSC is Underwritten by Unique Transcriptional and Epigenetic Alterations
Please visit Experimental Hematology online to view the winning abstracts.
2014 New Investigator Award Winners
PhD Students
1st Place: Albert D. Kim, University of California, San Diego, USA
Notch3 is Required in the Required in the Somitic Mircoenviroment for the Specification of Hematopoietic
2nd Place:: Jeffrey Bernitz, Ichan School of Medicine at Mount Sinai, USA
Label Retention Selects for Hematopoietic Stem Cells in Aged Bone Marrow and Distinguishes HSCs from Myeloid Restricted Progenitors
3rd Place: Jalal Ahmed, Mount Sinai School of Medicine/ MSTP, USA
Dactus Venosus-associated Pericytes form a Niche Regulating Hematopoietic Stem Cell Proliferation in the Fetal Liver
Post-doc
1st Place: Daniel D Lipka, German Cancer Research Center (DKFZ), GermanyWhole-genome Bisulfite Sequencing of HSCs and their Immediate Progeny Identifies Novel Regulatory Elements Involved in Self-renewal and Early Hematopoietic Commitment 2nd place: Magali Humbert, IRIC, Canada LM01/2 Regulates DNA Replication in Hematopoietic Cells 3rd place: Yoshihiro Hayashi, Cincinnati Children's Hospital Medical Center, USA Modeling and Targeting MLL-PTD/RUNX1 Related MDS/AML in Mouse
Please visit Experimental Hematology online to view the winning abstracts.
2013 New Investigator Award Winners
First Prize - Dirk van Bekkum Award (1st Place Student Award)
Karin Klauke - European Research Insitute for the Biology of Ageing(ERIBA), University Medical Centre Groningen, Netherlands Abstract Title: Clonal evolution of Leukemic Stem Cells in a Cbx7-induced Leukemia Mouse Model
Second Prize - T. Ray Bradley Award (2nd Place Student Award)
Kran Suknuntha - University of Wisconsin–Madison, Department of Pathology and Laboratory Medicine, United States
Abstract Title: Induced Pluripotent Stem Cell Model of Chronic Myeloid Leukemia Revealed Olfactomedin 4 as a Novel Therapeutic Target in Leukemia Stem Cells
Third Price - Greg Johnson Award (3rd Place Student Award)
Daichi Inoue - University of Tokyo Institute of Medical Science, Japan
Abstract Title: C-terminal-truncating ASXL1 Mutations induce MDS via Repression of PRC2 Function
First Prize – Eugene Cronkite Award (1st Place Post-doc Award)
Anna Beaudin - University of Califoria, Santa Cruz, United States
Abstract Title: Flk2 Lineage Tracing Reveals a Novel, Developmentally Restricted Hematopoietic Stem Cell
Second Prize - George Brecher Award (2nd Place Post-doc Award)
Emma de Pater - Erasmus MC, Netherlands
Abstract Title: Gata2 is Required for HSC Generation and Survival
Third Prize - Christa Muller-Sieburg Award (3rd Place Post-doc Award)
Isao Kobayashi
Abstract Title: Cell-to-cell Interaction Between Endothelialhematopoietic Precursors and Somites Regulates Developmental Specification of Hematopoietic Stem Cells through Notch Signaling
2012 New Investigator Award Winners
First Prize - Dirk van Bekkum Award (1st Place Student Award)
Brian Liddicoat - St Vincent's Institute of Medical Research, Melbourne, Australia
Abstract Title: ADAR1 is Essential for Erythroid Development
Second Prize - The T. Ray Bradley Award (2nd Place Student Award)
Bérengère de Laval - Institut Cochin, Paris, France
Abstract Title: Thrombopoietin Increases DNA Repair and Limits Hematopoietic stem Cell Long-term Injury and Mutagenesis in Response to DNA Damage
First Prize – The Eugene Cronkite Award (1st Place Post-doc Award)
Katie Foster - Cancer Research UK, London, United Kingdom
Abstract Title: Intravital Imaging of Human Hematopoietic Stem Cell Homing in the Bone Marrow Niche
Second Prize - George Brecher Award (2nd Place Post-doc Award)
Ayako Ishizu - Keio University, Tokyo, Japan
Abstract Title: Functions of Platelet Factor CLEC-2 in the Peri-Vascular Bone Marrow Niche: A Possible Trilateral Regulation of HSCs by Each Other, Their Progeny and Niche
2011 New Investigator Award Winners
First Prize - Dirk van Bekkum Award (1st Place Student Award)
Akanksha Chhabra - UCLA Molecular Biology Institute, Los Angeles, CA, USA
Abstract Title: Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling
Authors: A. J. Lechner, A. Acharya, M. Ueno, B. Van Handel, L. Iruela‐Arispe, M. Tallquist, H. Mikkola
Second Prize - The T. Ray Bradley Award (2nd Place Student Award)
Alessandro Di Tullio. Ph.D. Student, Center for Genomic Regulation, Spain
Abstract Title: C/EBPa induced pre-B cell to macrophage transdifferentiation causes selected progenitor gene reactivation without overt retrodifferentiation
Authors: Thien Phong Vu Manh, Alexis Schubert, Robert Månsson and Thomas Graf
First Prize – The Eugene Cronkite Award (1st Place Post-doc Award)
Amélie Montel-Hagen, Ph.D., post doc, UCLA, Los Angeles, USA
Abstract Title: Conversion of prospective hemogenic endothelium to cardiogenic fate in the absence of Scl/tal1
Authors: B. Van Handel, R. Ferrari, R. Sasidharan, H. Nakano, T. Org, J. Zhou, X. Li, M. Pellegrini, S. H. Orkin, A. Nakano, S. K. Kurdistani, H. K. Mikkola
2010 New Investigator Award Winners
First Prize - Dirk van Bekkum Award (1st Place Student Award)
T.C. Luis, Leiden University Medical Center, Leiden, Netherlands
Abstract Title: Canonical Wnt Signaling Regulates Hematopoiesis in a Dosage-Dependent Fashion
Second Prize - The T. Ray Bradley Award (2nd Place Student Award)
S.L. Ellis, Peter MacCallum Cancer Centre, East Melbourne, Australia
Abstract Title: HAS3-Synthesized Hyaluronan Participates in Directing the Preferential Homing of Transplanted Hemopoietic Stem Cells to the Metaphysis During the Initial Stages of Homing
First Prize – The Eugene Cronkite Award (1st Place Post-doc Award)
G.L. Swiers, University of Oxford, Oxford, United Kingdom
Abstract Title: Commitment of Endothelial Cells to a Hematopoietic Fate in the AGM Occurs Before E10.5
Second Prize - George Brecher Award (2nd Place Post-doc Award)
F. Ferraro, Harvard Stem Cell Institute, Massachusetts General Hospital, CRM, Boston, USA
Abstract Title: Diabetes Impairs Hematopoietic Stem Cell Trafficking
2009 New Investigator Award Winners
First Prize
Michael Heuser Abstract Title: TRANSCRIPTIONAL PROGRAM DEFINING CELLULAR SUSCEPTIBILITY TO MN1-INDUCED TRANSFORMATION (abstract #33)
Authors: 2 B. Argiropoulos, 2 E. Yung, 2 F. Kuchenbauer, 2 G. Park, 2 C. Lai, 3 N. Thiessen, 3 G. Robertson, 3 M. Hirst, 3 M. Marra, 1 A. Ganser, 2 R.K. Humprhies
1 Hannover Medical School, HANNOVER, Germany; 2 British Columbia Cancer Agency, VANCOUVER, Canada; 3 Genome Sciences Center, VANCOUVER, Canada
Second Prize*
Fumio Nakahara
Abstract Title: HES1 CONFERS SELF-RENEWAL CAPABILITY ON COMMITTED PROGENITORS AND INDUCES CHRONIC MYELOGENOUS LEUKEMIA BLASTIC CRISIS-LIKE DISEASE (abstract #27)
Authors: 1 J. Kitaura, 2 M. Sakata-Yanagimoto, 1 Y Komeno, 1 N. Kato, 3 K. Haraguchi, 4 K. Kumano, 5 Y. Harada, 5 H. Harada, 4 s. Ogawa, 4 M. Kurokawa, 2 S. Chiba, 1 T. Kitamura
1 The Institute of Medical Science, University of Tokyo, TOKYO, Japan; 2 Graduate School of Comprehensive Human Sciences, Univeristy of Tsukuba, IBARAKI, Japan; 3 Tokyo Metropolitan Cancer and Infectious Disease Center Komagome Hospital, TOKYO, Japan; 4 Graduate School of Medicine, The University of Tokyo. TOKYO, Japan; 5 Research Institute for Radiation Biology and Medicine, Hiroshima University, HIROSHIMA, Japan
Fernando Anjos-Afonso
Abstract Title: DISTINCTIVE CELLULAR/MOLECULAR SIGNATURES DEFINE THE QUIESCENCY AND PRIMITIVENESS OF HUMAN CD34NEG HEMATOPOIETIC STEM CELLS (abstract #01)
Authors: 2 H. Palmer, 1 D. Bonnet
1 Cancer Research UK, LONDON, United Kingdom;2 Laboratorio de Inventigacion Oncologica, Institut de Recerca Vall d'Hebron, BARCELONA, Spain
Teresa Bowman
Abstract Title: WNT AND BMP SIGNALING MODULATE HEMATOPOIETIC STEM AND PROGENITOR CELL ACTIVATION (abstract #08)
Authors: 2 A.K. Sessa, 2 M. McCarthy, 2 J.L. LeBlanc, 2 G. Heffner, 3 F. Rentzsch, 4 G. Weidinger, 5 J. Tucker, 3 M. Hammerschmidt, 6 R. Moon, 5 M. Mullins, 2 G.Q. Daley, 2 L.I Zion
1 Children's Hospital Boston, BOSTON, United States of America; 2 Children's Hospital Boston and HHMI, BOSTON, United States of America; 3 Max-Planck Institute for Immunobiology, FREIBURG, Germany; 4 University of Technology, DRESDEN, Germany; 5 University of Pennsylvania Medical School, PHILADELPHIA, United States of America; 6 University of Washington and HHMI, SEATTLE, United States of America
2008 New Investigator Award Winners
Please visit Experimental Hematology online to view the winning abstracts.
First Prize - Dirk van Bekkum Award (1st Place Student Award)
Jarrod A. Dudakov, New York, NY
Abstract Title: WITHDRAWAL OF SEX STEROIDS REVERSES AGE-RELATED DEFECTS IN MURINE HEMATOPOIETIC PROGENITOR CELL FUNCTION
Authors: Gabrielle L. Goldberg,2 Danika Khong,1 Ann P. Chidgey,1 Richard L. Boyd1
1Monash Immunology and Stem Cell Laboratories (MISCL), Monash University, Australia, 2Department of Immunology, Memorial Sloan-Kettering Cancer Center, New York, NY
First Prize – The Eugene Cronkite Award (1st Place Post-doc Award)
Daniel T. Starczynowski, Vancouver, BC, Canada
Abstract Title: IDENTIFICATION OF miR-145 AND miR-146a AS microRNAs INVOLVED IN THE PATHOGENESIS OF 5q- SYNDROME
Authors: Florian Kuchenbauer,2 Bob Agiropoulos,2 Sandy Sung,1 Connie Eaves,2 Wan Lam,3 Keith Humphries,2 Aly Karsan1
1Medical Biophysics, BC Cancer Research Centre, Vancouver, BC, Canada, 2Terry Fox Laboratory, BC Cancer Research Centre, Vancouver, BC, Canada, 3Cancer Genetics and Developmental Biology, BC Cancer Research Centre, Vancouver, BC, Canada
Second Prize - George Brecher Award (2nd Place Post-doc Award)
Wolfram Goessling, Boston, MA
Abstract Title: GENETIC INTERACTION BETWEEN PGE2 AND Wnt SIGNALING IN STEM CELL FORMATION AND ORGAN REGENERATION
Authors: M. Trista E. North,1 Sabine Schmitt,1 Allegra M. Lord,1 Sang Lee,3 Cristi L. Stoick-Cooper,4 Gilbert Weidinger,4 Mark Puder,3 George Q. Daley,1 Randall T. Moon,4 Leonard I. Zon1 1Stem Cell Program and Hematology/Oncology, Children’s Hospital, Boston, MA, 2Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA, 3Department of Surgery, Children’s Hospital, Boston, MA, 4Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA
2006 New Investigator Award Winners
First Prize - Dirk van Bekkum Award (1st Place Student Award)
Maria Johansson, Lund, Sweden
Abstract Title: Hematopoietic Stem Cell targeted Neonatal Gene Therapy Cures OC/OC Mice from Osteopetrosis
Authors: T. J. de Vries, M. Ehinger, V. Everts, S. Karlsson, J. Richter-Lund, Sweden
-- Tie for first place --
Andrew Wilber, Minneapolis, MN, USA
Abstract Title: Use of the Sleeping Beauty transposon system for Genetic engineering of Human Embryonic Stem Cell derived Hematopoietic Cells
Authors: J. L. Linehan, X. Tian, P. Woll, J. Morris, R. S.McIvor, D. S. Kaufman- Minneapolis, Minnesota
First Prize – The Eugene Cronkite Award (1st Place Post-doc Award)
Emily Thomas, Cincinnati, OH, USA
Abstract Title: RAC GTPASES are Critical for the Development of P210-BCR/ABL-mediated Chronic Myelogenous Leukemia (CML)
Authors: C. E. Harris, B. J. Druker, Y. Zheng, J. A. Cancelas, D. A. Williams-Cincinnati, OH
Second Prize - George Brecher Award (2nd Place Post-doc Award)
Bob Argiropoulos, Vancouver, Canada
Abstract Title: MEIS1 collaborates with a NUP98-HOX fusion to induce AML through FLT3-dependent and independent pathways
Authors: L. Palmqvist, F. Kuchenbauer, R. K. Humphries- Vancouver, Canada
2005 New Investigator Award Winners
First Prize - Dirk van Bekkum Award (1st Place Student Award)
Dr. Mattias Magnusson, Lund, Sweden
Abstract Title: HOXA10 Affects The Fate of Hematopopietic Cell In A Dose Dependent Manner
Authors: A.C.M. Brun, N. Miyake, E. Nilsson, J. Bjornsson, S. Karlsson – Lund, Sweden
Second Prize - The T. Ray Bradley Award
Dr. Rhonna Gurevich, Vancouver, Canada
Abstract Title: Retroviral Integration Site Analysis Identifies ICSBP As A Collaborating Tumor Suppressor Gene In NUP98-TOP Induced Leukemia
Authors: P.M. Rosten, C. Stocking, R.K. Humphries – Vancouver, Canada
First Prize - The Eugene Cronkite Award
Dr. Marta Serafini, Milano, Italy
Abstract Title: Mulitpotent Adult Progenitor Cells(MAPCS) Can Provide Lymphohematopoietc Reconstitution in Lethally Irradiated Immunodeficient Mice
Authors: Y. Jiang, M. Oki, S. Buckley, A. Panoskaltsis-Mortari, M.J. O’Shaughnessy, B. R. Blazar, C. M. Verfaillie – Minneapolis, MN, USA
Second Prize – George Brecher Award
Dr. Shao An Xue, London, United Kingdom
Abstract Title: Development of WTI-Specific CTL For The Treratment of Human Leukemia Through TCR Gene Transfer
Authors: L. Gao, D. Hart, R. Gillmore, W. Qasime, A. Thrasher, W. Uckert, E. Morris, H. Stauss – London, UK
The ISEH is pleased to recognize Kirin Brewery Company, Limited for its support of the ISEH New Investigator Awards
2004 New Investigator Award Winners
First Prize - The T. Ray Bradley Award
Dr. Erin Drew, Vancouver, Canada
Abstract Title: CD34 and CD43 Block Mast Cell Adhesion and Are Required for Optimal aMast Cell Reconstitution
Authors: J. Merzaban, H. Merkens, S.J. Chelliah, H.J. Ziltener, K.M. McNagny – Vancouver, Canada
First Prize - The T. Ray Bradley Award
Dr. Craig Eckfeldt, Minneapolis, MN, USA
Abstract Title: Differential Gene Expression Patterns During Lineage Commitment of Human Hematopoietic Stem Cells
Authors: E.M. Mendenhall, S.C. Ekker, C.M. Verfaillie – Minneapolis, MN, USA
Second Prize - The Eugene Cronkite Award
Dr. Maria Vogiatzi, New York, NY, USA
Abstract Title: Study of Bone Disease in Thalassemia Using a New Cooley’s Anemia Adult Mouse Model
Authors: I. Chaikhoutdinov, A.L. Boskey, E.R. Myers, S. B. Doty, S. Rivella – New York, NY, USA
The ISEH is pleased to recognize Kirin Brewery Company, Limited for its support of the ISEH New Investigator Awards
2003 New Investigator Award Winners
First Prize - The T. Ray Bradley Award
Dr. Vanta Jokubaitis, Melbourne, Australia
Abstract Title: Expression of Angiotensin Cnverting Enzyme (ACE) marks the emergence of the human hematopoietic system and identifies candidate hematopietic stem cells in neonatal and adult tissues
Authors: V. Jokubaitis, M. Tavian, D. Haylock, I. Bertoncello, B. Williams, R. Driessen, B. Peault, P. Simmons - Melbourne, Australia
Second Prize - The Eugene Cronkite Award
Dr. H. Iwasaki, Boston, MA, USA
Abstract Title: Esinophil-committed progenitors are generated from granulocyte/monocyte progenitors by instructive action of GATA-2
Authors: H. Iwasaki, S. Mizuno, H. Shigematsu, K. Takatsu, K. Akashi - Boston, MA USA
Third Prize - The Dirk van Bekkum Award
Dr. Yves Pastore, Houston, TX, USA
Abstract Title: Mutations of Con Hippel-Lindau tumor suppressor and congenital polycthemia
Authors: Y.D. Pastore, E. Liu, K. Jedlickova, Y. Guan, H. Hasle, J. Prchal - Houston, TX, USA
The ISEH is pleased to recognize Kirin Brewery Company, Limited for its support of the ISEH New Investigator Awards
2002 New Investigator Award Winners
First Prize - The T. Ray Bradley Award
Dr. Stefano Rivella, New York, NY, USA
Abstract Title: A New Adult Mouse Model of lethal b0-Thalassemia and Its Rescue by Lentivirus Mediated Globin Gene Transfer
Authors: S. Rivella, C. May, A. Chadburn, I. Riviere, M. Sadelain- New York, NY, USA
Second Prize - The Eugene Cronkite Award
Dr. Mark W. Drummond, Glasgow, UK
Abstract Title: hTERT gene expression is increased by alternative splicing of mRNA during the Course of CML, and telomere loss at diagnosis is associated with early progression
Authors: M. Drummond, S. Hoare, M. Alcorn, S. Graham, W. Keith, T. Holyoake - Glasgow, UK
Third Prize - The Dirk van Bekkum Award
Dr. Peter Horn, Seattle, WA, USA
Abstract Title: Highly efficient lentriviral of NOD/SCID repopulating cells but not long-term repopulating cells in the baboon in a direct comparison of the NOD/SCID assay versus autologous transplantation
Authors: P. Horn, B. Thomasson, J. Morris, H.-P. Kiem - Seattle, WA, USA
The ISEH is pleased to recognize Kirin Brewery Company, Limited for its support of the ISEH New Investigator Awards
2001 New Investigator Award Winners
First Prize - The Dirk van Bekkum Award
Dr. Brenton Short, Melbourne, Australia
Abstract Title: Prospective Isolation of Stromal Progenitors from Mouse Compact Bone. 266
Authors: B Short, N Brouard, R Driessen, PJ Simmons - Melbourne, Australia
Second Prize - The T. Ray Bradley Award
Dr. Timm Schroeder, Munich, Germany
Abstract Title: Disruption of the Mouse RBP-J Gene Alters Development of Mesodermal Cell Lineages Derived from Embryonic Stem Cells. 264
Authors: T Schroeder, S Fraser, M Ogawa, S Nishikawa, C Oka, G Bornkamm, S-I Nishikawa, T Honjo, U Just - Munich, Germany
hird Prize - The Eugene Cronkite Award
Dr. Takuya Matsunaga, Sapporo, Japan
Abstract Title: VLA4 (α4β1 Integrin) Protect Acute Leukemia Cells from Undergoing Apoptosis by Chemotherapeutic Drugs: A Possible Mechanism for Refractoriness of Acute Myelogenous Leukemia (AML) to Chemotherapy. 269
Authors: T Matsunaga, S Sakamaki, N Takemoto, A Fujimi, Y Konuma, T Akiyama, T Kusakabe, H Kuroda, Y Niitsu - Sapporo, Japan
The ISEH is pleased to recognize Kirin Brewery Company, Limited for its support of the ISEH New Investigator Awards
2000 New Investigator Award Winners
First Prize - The Eugene Cronkite Award
Dr. Christian Buske, Vancouver, BC, Canada
Abstract Title: HOXA10 - OVEREXPRESSION CAUSES SEVERE PERTURBATIONS IN HUMAN HEMATOPOIESIS. 169
Authors: C. Buske, M. Feuring-Buske, J. Antonchuk, P. Rosten, D. Hogge, C. Eaves, R. Humphries, Vancouver, Canada
Second Prize - The Dirk van Bekkum Award
Dr. Shuli Zhang, Stanford, CA, USA
Abstract Title: FLT3 LIGAND INDUCES FUNCTIONAL EFFECTS THROUGH STAT5A ACTIVATION AND BCL-XL EXPRESSION AS EVIDENCED THROUGH BIOCHEMICAL ANALYSIS AND USE OF STAT 5A -/- MICE. 214
Authors: S. Zhang, Y. Lee, G. Hangoc, S. Cooper, W. Leonard and H. Broxmeyer,
Bethesda, Maryland, USA
Third Prize - The T. Ray Bradley Award
Feng-Chung Yang, Indianapolis, Indiana, USA
Abstract Title: RAC2 REGULATES THE ACTIVATION OF AKT AND THE BALANCE BETWEEN PRO- AND ANTI-APOPTOTIC PROTEINS BAD AND BCL-XL. 116
Authors: F. Yang, R. Kapur, A. King, W. Tao, J. Borneo and D. Williams,
Indianapolis, Indiana, USA
The ISEH is pleased to recognize Kirin Brewery Company, Limited for its support of the ISEH New Investigator Awards
1999 New Investigator Award Winners
First Prize
Dr. Robert Pawliuk, Cambridge, Mass, USA
Abstract Title: Long-Term cure of a mouse model of erythropoietic protoporphyria by preselective gene therapy.
Authors: R. Pawliuk, T. Bachelot, R. Wise, M.M. Mathews-Roth and P. Leboulch
Second Prize
Dr. Harald Schulze, Hannover, Germany
Abstract Title: Thrombopoietin induces distinct stat complexes in human platelets with different kinetics.
Authors: H. Schulze, M. Germeshausen, K. Welte and M. Ballmaier
Third Prize
Dr. Maria T. Corsetti, Genova, Italy
Abstract Title: "Cytogenetic response to autografting in CML patients depends on the amount of BCR-ABL positive cells in the graft and on the duration of the disease before autografting."
Authors: M.T. Corsetti, E. Lerma, A. Dejana, P. Basta, R. Ferrara, F. Benvenuto, F. Vassallo, M. Abate, G. Piaggio, C. Parodi, M. Sessarego, G. Li Pira, F. Manca and A.M. Carella
The ISEH is pleased to recognize Kirin Brewery Company, Limited for its support of the ISEH New Investigator Awards
1998 New Investigator Award Winners
First Prize
Dr. Nobuyuki Takakura
Institute of Molecular Embryology and Genetics
Kumamoto University School of Medicine
Japan
Second Prize
Dr. Liqing Jin
University of Washington
Seattle, WA USA&
Third Prize
Dr. Gerald de Haan
University of Gröningen
The Netherlands
The ISEH is pleased to recognize Kirin Brewery Company, Limited for its support of the ISEH New Investigator Awards