Registration Open

New Investigators Pre-Meeting Workshop*

Join us for a pre-meeting workshop designed for PhD students and postdoctoral fellows with a focus on collaboration. Learn more.

*Ticketed event. Additional purchase required.

2026 symposium on “Human pluripotent stem cell-derived hematopoiesis”* 

*This is an event planned by another organizer and is not an official ISEH event. For more details, please visit the event website. 

Translational hematology: Towards chemo-free therapy in hematologic malignancies*

This free symposium will feature world-leading scientists presenting research and the latest developments in tranlsational hematology and a focus of building a future towards chemo-free therapy in hematologic malignancies. Speakers to be announced. Learn more.

*You have the option to add this free symposium to your ISEH registration, or to only register for this free symposium.

Junior Faculty Networking Workshop*

Join the ISEH Junior Faculty Committee for an educational and networking workshop with fellow new faculty members.

*Ticketed event. Additional purchase required.

Scientific Session 1: Donald Metcalf Award Lecture

2026 Donald Metcalf Award Winner: Ellen Rothenberg, PhD, California Institute of Technology, USA
How T lymphoid cell identity emerges from hematopoietic molecular mechanisms (1001)

Alejo Rodríguez Fraticelli, PhD, IRB Barcelona and ICREA, Spain
Thinking fast and slow: origins and consequences of stem cell biases (1002)

Scientific Session 2A (concurrent): Malignant Microenvironments

Monica Guzman, PhD, Weill Cornell Medicine, USA
TBA (1003)

Adam Benabid, RWTH Uniklinik Aachen, Germany
Reversal of human bone marrow fibrosis through stromal-immune rewiring and PDE5A inhibition (2001)

Karin Prummel, Molecular Systems Biology Unit, EMBL Heidelberg, Heidelberg, Germany
Perturbation of leukemic stem cell states reveals a TGFβ-driven niche remodeling program in AML (2002)

Inés Simó Vesperinas, Berlin Institute of Health (BIH), Germany
MHC-II–mediated CD4 T cell engagement overcomes the differentiation block in acute myeloid leukemia (2003)

Scientific Session 2B (concurrent): Human Developmental Hematopoiesis

Vincenzo Calvenese, PhD, Josep Carreras Leukaemia Research Institute, Spain
Establishing and Maintaining the Human Hematopoietic Stem Cell Program (1004)

Júlia Viladevall, University of Cambridge / Cambridge Stem Cell Institute, UK
Clonally resolved dynamics of human haematopoietic in vitro differentiation across ontogeny (2004)

Joan Pera, Josep Carreras Leukemia Research Institute, Spain
SAMD9 Gain-of-Function Disrupts Hematopoiesis and Is Partially Rescued by Secondary Loss-of-Function in iPSC Models (2005)

Quynh Nguyen, McEwen Stem Cell Institute, UHN, Canada
CD49F expression marks molecularly and functionally distinct yolk sac (2006)

Scientific Session 2C (concurrent): Progenitor Biology

Yoon-A Kang, PhD, Washington University in St. Louis, USA
Rewiring Progenitor Heterogeneity: Integration of Lymphoid Features into Emergency Myelopoiesis (1005)

James Palis, University of Rochester Medical Center, USA
A multistep Flk-independent pathway of hematopoietic differentiation is preferentially responsive to marrow injury and generates functionally distinct platelets and neutrophils (2007)

Daniel Lipka, German Cancer Research Center (DKFZ), Germany
Sub-DMR methylation states resolve early hematopoietic commitment decisions (2008)

Tamim Sarakpi, Goethe University, Department of Nephrology, Germany
Trained Immunity in the Bone Marrow Links Metabolic and Uremic Stress to Cardiovascular Injury (2009)

Scientific Session 3A (concurrent): Metabolism in Myeloid Diseases

Kevin Rouault-Pierre, PhD, Queen Mary University of London / Leukemia Institute Paris Saint Louis, UK
Metabolic intervention in SF3B1-Myelodysplastic Neoplasms (1006)

Elisa Donato, DRK-Blutspendedienst, Germany
Intracellular Cholesterol Sequestration in Multivesicular Bodies Drives Metabolic Quiescence and LSC Persistence in DNMT3A/NPM1-mutated AML (2010)

Anna-Lena Schmell, Goethe University Frankfurt, Germany
Pathway-Guided Interception of Down Syndrome-Associated Leukemogenesis (2011)

Peter Kurre, MD, University of Pennsylvania/ Children's Hospital of Philadelphia, USA
Cellular iron homeostasis and hematopoiesis failure in Fanconi Anemia (1007)

Scientific Session 3B (concurrent): Clonal Hematopoiesis

Siddhartha Jaiswal, MD, PhD, Stanford University, USA
TBA (1008)

Satish Nandakumar, Albert Einstein College of Medicine, UAS
Identification of clonal hematopoiesis associated-genetic variants that perturb regulatory elements in hematopoietic stem and progenitor cells. (2012)

Amanda Jiminez-Pompa, Queen Mary University of London, UK
In vivo CRISPR/Cas9-mediated modelling of clonal haematopoiesis via a multi-lox Hydra allele (2013)

Rob Welner, PhD, The University of Alabama at Birmingham, USA
Microenvironmental Remodeling of Mutant Cell Fitness During Hematopoietic Disease Progression (1009)

Scientific Session 3C (concurrent): Lymphoid Malignancies

Gemma Kelly, PhD, WEHI, Australia
Informing therapeutic approaches for TP53 mutant blood cancers (1010)

Lucy Hamer, University of Oxford, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, UK
Down Syndrome fetal liver haematopoietic progenitors fail to provide a permissive cell context for KMT2A::AFF1 infant acute lymphoblastic leukaemia initiation (2014)

Laura Geurrero, Ghent University, Belgium
Nicotinamide phosphoribosyltransferase inhibition sensitizes acute lymphoblastic leukemia to antifolate therapy (2015)

Jan Cools, PhD, VIB-KULeuven, Belgium
TBA (1011)

Scientific Session 4: Presidential Symposium

Luigi Naldini, MD, PhD, San Raffaele Telethon institute for Gene Therapy (SR-Tiget), Italy
TBA (1014)

The EMBO Keynote Lecture: Sten Eirik Jacobsen, MD, PhD, Karolinska Instituet, Institute of Medicine, Huddinge (MedH) and Department of Cell and Molecular Biology (CMB), Sweden
In vivo clonal fate-mapping of hematopoietic stem cells in mice and humans (1013)

Cristina Lo Celso, PhD, Imperial College London, UK
TBA (1012)

Lizzy Morritt, University of York, UK
Architecture of the TPO-MPL Signalling Complex: Defining the Role of CRM2 in Receptor Scaffolding and Allosteric Control (2016)

Featured Posters x9

Brandon Gheller, Boston Children's Hospital, USA
Phosphatidylcholine Synthesis Inhibition Diminishes ASXL1, TET2, and DNMT3a Mutation Driven Clonal Expansion via Platelet Activating Factor Signaling (3001)

Rachel Wellington, Fred Hutchinson Cancer Center, USA
Decoding the Embryonic Origins of Highly Engraftable “Super” HSCs (3002)

Terri Cain, St. Jude Children's Research Hospital Graduate School of Biomedical Sciences, USA
Epigenetic Dysregulation and Niche Engagement Dysfunction of Sickle Cell Disease Hematopoietic Stem Cells (3003)

Gabriela Feurstein, University of Veterinary Medicine, Vienna, Austria
STAT5B functions as a sex-specific regulator of hematopoiesis (3004)

Karina Jiminez Camacho, Cincinnati Children's Hospital Medical Center, USA
RMND1 is a polyamine‑dependent vulnerability in acute myeloid leukemia (3005)

Susann Rahmig, Weatherall Institute of Molecular Medicine, University of Oxford, UK
Stromal niche remodeling with expansion of interferon-responsive, HSC-supportive MSCs in human clonal hematopoiesis (3006)

Roopsha Bandopadhyay, University of Pennsylvania, USA
The role of inflammation in clonal response to FLT3 inhibition (3007)

Daniel Aldridge, Columbia University, USA
Trained immunity engages a conserved emergency myelopoiesis program to reprogram HSPCs (3008)

Lucas Ruffinatto, CIML, France
HSCs encode past stimulation memory to shape innate immune adaptation (3009)

Scientific Session 5A (concurrent): Mechanisms of Drivers of AML

Linde Miles, PhD, Cincinnati Children's Hospital Medical Center, USA
NRAS codon mutations confer distinct disease characteristics in AML and exhibit differential response to pan-RAS inhibitors (1015)

Jinyu Su, Finsen Laboratory/BRIC, University of Copenhagen, Denmark
ARID1B-dependent enhancer rewiring sustains KMT2A-MLLT3 leukemia and exposes a therapeutic vulnerability (2017)

Robert Winkler, Goethe University Frankfurt, Germany
An Integrated Epigenomic Atlas Defines Master Transcription Factor Circuits in Pediatric AML (2018)

Wei Tong, PhD, University of Pennsylvania School of Medicine and Children's Hospital of Philadelphia, USA
MHC II-driven immunity in malignant hematopoietic stem and progenitor cells (1016)

Scientific Session 5B (concurrent): Cell Therapies

Saar Gill, MD, PhD, University of Pennsylvania, USA
Engineering the tumor microenvironment using genetically modified hematopoietic stem cell transplantation (1017)

Kohei Shiroshita, San Raffaele Teleton Insitute for Gene Therapy (SR-Tiget), Italy
Novel selection strategy enriches human hematopoietic stem and progenitor cells with homology-directed repair (2019)

Ali Motazedian, Peter MacCallum Cancer Centre, Australia
A conserved transcriptional program dictates the engraftment of ex vivo expanded HSCs (2020)

Colleen Delaney, MD, MSc, Seattle Children's Research Institute, USA
TBA (1018)

Scientific Session 5C (concurrent): Lymphoid Cells and the Microenvironment

Joji Fujisaki, MD, PhD, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Bone marrow niches orchestrate stem-cell hierarchy and immune tolerance (1019)

Ximing Li, University of Toronto, Canada
IFNγ Drives Long-Term Bone Marrow Niche Dysfunction Following Chemotherapy (2021)

Andrea Ditadi, Ospedale San Raffaele, Italy
Embryonic lymphocytes contribute to a genetic form of autoimmune inflammation (2022)

Stéphane Mancini, PhD, INSERM, University of Rennes, France
Bone marrow microenvironment in normal and leukemic B cell development: friend or foe? (1020)

Scientific Session 6: New Investigator Award Lecture

Nina Cabezas-Wallscheid, PhD, ETH Zürich - Swiss Federal Institute of Technology, Switzerland
TBA (1021)

PhD Students

Jan Barinka, E Berlin Institute of Health (BIH) at Charité, Germany
Coordinated interactions across biological scales define disease trajectories in acute myeloid leukemia (2023)

Hiromitsu Harimoto, Cambridge Stem Cell Institute, UK
ChronoClone: Integrating Time-Resolved Single-Cell Transcriptomics and Lineage Tracing to Quantify Clonal Differentiation Dynamics (2024)

Denis Masnikov, Inserm UMR1231 CTM, University Bourgogne Europe, France
PRMT2 drives adhesion-dependent cytoskeletal signaling and leukemic progression through a VAV1-coupled pathway in acute myeloid leukemia (2025)

Postdoctoral Fellows

Alba Rodriguez Meira, Dana Farber Cancer Institute, USA
Scalable single-cell DNA methylation reveals a stepwise epigenetic logic disrupted in clonal hematopoiesis (2026)

Miguel Quijada-Alamo, Icahn School of Medicine at Mount Sinai, USA
Developmental Stage Shapes Lineage Fate and Reveals a Targetable Pre-Leukemic State in BCR::ABL1-Driven Leukemia (2027)

Anna Konturek-Ciesla, ETH Zürich - Swiss Federal Institute of Technology, Switzerland
Molecular Regulation of Cell Fate Divergence in Asymmetric Division of Hematopoietic Stem Cells (2028)

Meet the Experts Networking Lunch*

Experts include: Ellen Rothenberg, Eirini Papapetrou, Beth Psaila, Mick Milsom, Katherine King, Louise Purton, Nina Cabezas-Wallscheid, Gemma Kelly, Bertie Göttgens, and Lars Velten. 

*The Meet the Experts Networking Workshop is an add-on ticket that can be added to your registration. If you have already registered, but would still like to purchase a ticket to the social event, you can do so here.

Scientific Session 7: ISEH/EHA Joint Session: Genetic Predisposition to Blood Cancer (Rare Diseases)

Jörg Cammenga, MD, Lund University, Sweden
Inherited Bone Marrow Failure and Germline Predisposition to Myeloid Neoplasia: Somatic Genetic Reversion and Clonal Adaptation in Hematopoietic Stem Cells (1022)

Simone Feurstein, MD, University Hospital Heidelberg, Germany
RUNX1 at the Interface of Hematopoiesis, Inflammation, and the Bone Marrow Microenvironment (1023)

Scientific Session 8: Paul S. Frenette Lecture

Anastasia Tikhonova, PhD, Princess Margaret Cancer Center, Canada
Prefibrotic Bone Marrow Microenvironment is a Hallmark of Clonal Hematopoiesis (1024)

Featured Posters x5

Yara Lackousha, DKFZ, Germany
Arsenic Trioxide and Cytarabine combination overcomes Venetoclax–Azacitidine resistance in relapsed AML in vivo (3010)

Ayşegül Erdem, de Duve Institute, UCLouvain, Belgium
Targeting PFKFB4 to Disrupt Antioxidant Homeostasis and OXPHOS Dependency in Acute Myeloid Leukemia (3011)

Virgina Turati, Lund University, Sweden
Reconstructing childhood ALL population dynamics from diagnosis to relapse: a systems biology approach (3012)

Karina Jimenez Camacho, Cincinnati Children's Hospital Medical Center, USA
RMND1 is a polyamine‑dependent vulnerability in acute myeloid leukemia (3013)

Satoshi Koi, The University of Tokyo, Japan
Role of the cGAS-STING pathway in the pathogenesis of myelodysplastic syndromes (3014)

Social Event*

*Ticketed event. Additional purchase required.

Scientific Session 9: Janet Rowley Award Lecture

2026 Janet Rowley Award Winner: Beth Psaila, MD, PhD, University of Oxford, UK
TBA (1025)

Cih-Li Hong, University of Rochester Medical Center, USA
Intravital Imaging of Calcium Network Topology Revealed the Immune-Modulatory Loci in the Bone Marrow (2029)

Borhane Guezguez, University Medical Center Mainz, Germany
Stepwise inflammatory remodeling of the human bone marrow niche in CHIP and MDS (2030)

Krzysztof Szade, Jagiellonian University, Poland
A non-canonical pathway for red blood cell clearance mediated by bone marrow endothelial cells (2031)

Scientific Session 10A (concurrent): Predicting HSPC Function

Bertie Göttgens, DPhil, FMedSci, Cambridge Stem Cell Institute, University of Cambridge, UK
From Stem Cell States to Stem Cell Flux (1026)

Megan Guthrie, University of York, UK
Defining the proteomic landscape of haematopoietic stem and progenitor cells across transplantation sources (2032)

Marella de Bruijn, PhD, Oxford University, UK
Resolving hematopoietic stem versus progenitor cell potential in the mouse dorsal aorta by differential Runx1+110 enhancer activity (2033)

Ingmar Glauche, Technische Universität Dresden, Germany
From data to dynamics: mechanistic modeling of clonal time courses reveals heterogeneity and quiescence of hematopoietic stem cells (2034)

Scientific Session 10B (concurrent): Targeting Leukemia Initiating Cells in Myeloid Malignancies

Peter van Galen, PhD, Brigham and Women's Hospital, Harvard Medical School, USA
Targeting Protein Translation to Preempt Adaptation of Leukemia Cells Undergoing Therapy (1027)

Maxime Sajot, Cancer Research Centre of Toulouse (INSERM UMR1037), France
Lipoylation Pathway Dependency in Leukemic Stem Cells Confers Vulnerability to Cuproptosis (2035)

Zhen Jin, University of British Columbia, Canada
LncRNA-mediated organization of an oncogenic chromatin state is a targetable vulnerability in leukemia (2036)

Alexander Waclawiczek, German Cancer Research Center, Germany
Leukemic stem cell subtypes determine venetoclax resistance and therapeutic vulnerabilities in AML (2037)

Scientific Session 10C (concurrent): HSC Microenvironments

Konstantinos Kokkaliaris, PhD, Dr Senckenberg Institute of Pathology, Germany
TBA (1028)

Tiago Luis, Imperial College London, Centre for Inflammatory Disease, Department of Immunology and Inflammation, UK
A new double reporter strategy reveals a subset of non-migratory hematopoietic stem cells located in a dynamic bone marrow niche (2038)

Julia Landberg, Lund Stem Cell Center, Lund University, Sweden
Mass Spectrometry-Based Secretome Profiling Reveals Shared Remodeling of the Bone Marrow Microenvironment in Aging and Tet2-Mutant Clonal Hematopoiesis (2039)

Susanne van den Brink, Sanquin Research, Netherlands
Gastruloids capture multi-wave hematopoiesis with spatial and temporal accuracy (2040)

Scientific Session 11A (concurrent): Novel Tools to Study Hematopoiesis

Lars Velten, PhD, Centre for Genomic Regulation, Spain
Perturb-seq defines co-regulated gene programs shaping hematopoietic stem and progenitor cell function (1029)

Licyel Paulas Condori, Cambridge Stem Cell Institute - University of Cambridge, UK
Decoding human haematopoiesis across scales using a haematopoiesis-in-a-dish system (2041)

Stephen Loughran, University of Cambridge, UK
The Landscape of Somatic Retrotransposon Mutations in HSCs, and a novel JAK2 Signalling Pathway to HNRNPA1 that protects the HSC genome from retrotransposons (2042)

Andrea Polazzi, University of Basel, Switzerland
Leukemia stem cell expansion cultures reveal clonal drivers of leukemogenesis and therapy response (2043)

Scientific Session 11B (concurrent): Prenatal Hematopoiesis in the Embryo and Adult

Elisa Gomez Perdiguero, PhD, Institut Pasteur, France
Contribution of developmental hematopoiesis to health and disease (1030)

Brian Krum, University of Utah, USA
Divergent Mitochondrial Programming of Hematopoietic Stem Cell Function by Maternal Folate Status (2044)

Marcel Rommel, Institute for the Biology of Stem Cells, University of California-Santa Cruz, USA
Origins of Immune Resilience: Neonatal Hematopoietic Stem Cells Encode Lifelong Immune Competence and Healthspan (2045)

Laura Bennett, The Jackson Laboratory, USA
Restraint of TGFb/BMP signaling is necessary for the maturation of hematopoietic stem cells in the mouse embryo (2046)

Scientific Session 11C (concurrent): HSCs During Aging

Verena Korber, PhD, Weatherall Institute of Molecular Medicine, UK
Selection dynamics in human hematopoietic stem and progenitor cells during aging and malignant transformation (1031)

Monica Kasbekar, Columbia University Irving Medical Center, USA
Aging enhances IL-1β responsiveness in human bone marrow hematopoietic stem cells (2047)

Xinran Huang, MRC Weatherall Institute of Molecular Medicine, UK
A distinct role for blood aldehyde catabolism in hematopoietic aging (2048)

Frieda Zimmer, Department of Pediatrics, Division of Infectious Disease, Baylor College of Medicine and Texas Children’s Hospital, USA
Loss of function Dnmt3a mutation leads to aberrant neutrophil migration (2049)

Scientific Session 12: McCulloch and Till Award Lecture

NIC Pre-Meeting Workshop Winner
TBA (2050)

2026 McCulloch and Till Award Winner: Eirini Papapetrou, MD, PhD, Icahn School of Medicine at Mount Sinai, USA
Decoding the clonal evolution of myeloid malignancy through iPSC reprogramming (1032)

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