The 2024 Donald Metcalf Award goes to Dr. Emmanuelle Passegué for her outstanding work in the fields of normal and malignant hematopoietic stem cell biology. Dr. Passegué, Alumni Professor of Genetics & Development and Director of the Columbia Stem Cell Initiative (CSCI) at Columbia University Irving Medical Center in New York city, receives the highest honor bestowed by the Society for her distinguished work as an outstanding scientist, leader, and role model.
Dr. Passegué grew up in France, and after PhD studies at the Collège de France in Paris she went on to postdoctoral research, first with Dr. Erwin Wagner at the Institute of Molecular Pathology in Vienna and with Dr. Irv. Weissman at Stanford University. In 2005, she started her own independent research group at the University of California at San Francisco (UCSF), where she became full Professor in 2014. In 2017, she moved to Columbia University, where she became the director of their Stem Cell program, further proving her engagement as leader and mentor.
Dr. Passegué has made seminal contributions to our understanding of mechanisms that regulate hematopoietic stem cells and blood production, how these are affected in contexts such as normal aging, stress, or inflammation, and can be targeted to help developing new therapeutic and anti-aging interventions. Her work established important new hallmark features of an old state in the blood system, identified key aspect of the bone marrow niche important for normal and malignant hematopoiesis, and dissected novel mechanisms of myeloid cell amplifications. In addition to her groundbreaking contributions to the field, Dr. Passegué has assumed the role of mentor for many younger scientists, encouraging and supporting them in their careers. A Past President of ISEH in 2019, Dr. Passegué was also awarded the McCulloch and Till Award in 2014 and the William Dameshek prize from the American Society of Hematology in 2019. Within ISEH, she has shown a long-standing commitment throughout her career and has greatly contributed to the development of the community. Dr. Passegué signifies an exceptional scientist, leader and role model for future researchers.
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